Newcastle disease


Newcastle disease is an infection of domestic poultry and other bird species with virulent Newcastle disease virus (NDV). It is a worldwide problem that presents primarily as an acute respiratory disease, but depression, neural disturbances or diarrhea may be the predominant clinical form.


Newcastle disease virus (NDV), synonymous with avian paramyxovirus serotype 1 (PMV-1), is an RNA virus and the most important of the 11 known PMV serotypes as a pathogen for poultry. Transmission occurs by exposure to faecal and other excretions from infected birds, and through contact with contaminated food, water, equipment, and clothing.

3. CLINICAL SIGNS: NDV strains can be categorised as 3 stages

  • Velogenic (highly virulent): causes severe nervous and respiratory signs, spread rapidly, and cause up to 90% mortality, infected animal can be dead within 25 – 48 hours with noticable symptoms such as: anorexia, lethargy, ruffled feathers, droopy head, high fever, breathlessness…
  • Mesogenic (intermediate virulence): early symptoms can be lethargy, droopy head and drooped wings… the infected animals seem to be slow and tired and they usually gather in large group and stand alone..
    • Injected animals got a high fever ranging from 43,5 – 44oC, sneeze continously, breathlessness.
    • There are pooled plague fluid around their head, eyes. There are constant leaked of cerebrospinal fluid from the nostril.
    • Severe bacterial diarrea with white, blue, some times even mix with blood dropping…
    • Egg production and egg quality fell drastically. Blood spots can be found on the surface of egg yolks. Eggs have abnormal in color, shape, or surface and have watery albumen.
  • Lentogenic (nonvirulent): usually there are mild symptoms with negligible mortality such as leg paralysis, wry head, epileptic seizures when stimulated by big noises.


- There is no treatment, antibody has minmum effect.

- You can give AVINEW NEO vaccine from Merial, France, administer orally with a double concentration, eye or nose instillation with a half as much centration.


  • Apply proper veterinary hygiene measures.
  • Isolate the sick from the healthy.
  • Disinfect the coop once a week.
  • Give adjuvant drugs that is manufactured by SANFOVET to enhance natural resistance such as: 


  • If NDV strains to Velogenic stage, it would be impossible to save the flocks. But NDV is spotted at Lentogenic stage, should vaccine treatment is applied immediately, 60 – 70 % of the flock can be saved. It is advisable that antibiotic should be given to minimize the risk of relapse.
  • Select from one of the following antibiotics:

AZ. AMOXI - COL  20% : 1 g / 15 - 20 b.w / day
TIMIMAX  : 1 ml / 10 - 15 b.w / day
AMPI – COLI EXTRA : 1 g / 8 - 10 b.w / day

Select one from the mentioned products, apply treatment for 5 – 7 days consecutively.

Note: On the first 2 days of treatment period, increase the concentration to half as much of the recommended dosage. On the remaining period, administer according to the suggested dosage.


Know-How, Poultry